Invention Grant
- Patent Title: Method for preparing anti-heart-failure medicine LCZ696
-
Application No.: US16060297Application Date: 2016-06-06
-
Publication No.: US10221145B2Publication Date: 2019-03-05
- Inventor: Guorong Zhu , Yongjun Tu , Wenlong Xie , Zhen Wang , Shaojun Xu
- Applicant: ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Taizhou, Zhejiang
- Assignee: ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD.
- Current Assignee: ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Taizhou, Zhejiang
- Agency: Novick, Kim & Lee, PLLC
- Agent Allen Xue
- Priority: CN201510903519 20151209
- International Application: PCT/CN2016/084914 WO 20160606
- International Announcement: WO2017/096772 WO 20170615
- Main IPC: C07D257/02
- IPC: C07D257/02 ; B01D9/00 ; A61P9/12

Abstract:
The present invention discloses a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following step (formula (I)): in an organic solvent, a Sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved.
Public/Granted literature
- US20180354915A1 METHOD FOR PREPARING ANTI-HEART-FAILURE MEDICINE LCZ696 Public/Granted day:2018-12-13
Information query