Invention Grant
- Patent Title: N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors
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Application No.: US16051816Application Date: 2018-08-01
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Publication No.: US10221174B2Publication Date: 2019-03-05
- Inventor: Shaomeng Wang , Jianyong Chen
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61P35/00
Abstract:
The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b, E, and are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.
Public/Granted literature
- US20180354950A1 N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS Public/Granted day:2018-12-13
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