![Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1](/docs/US/2019-03-05/US10221175B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1
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Application No.: US15568936Application Date: 2016-04-22
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Publication No.: US10221175B2Publication Date: 2019-03-05
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Changho Han , Julie L. Engers , Aaron M. Bender
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2016/028940 WO 20160422
- International Announcement: WO2016/172547 WO 20161027
- Main IPC: A61K31/395
- IPC: A61K31/395 ; C07D471/14 ; A61K31/506 ; A61K31/513 ; A61K31/517 ; A61K31/519 ; A61P25/28 ; A61P25/00
![Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1](/abs-image/US/2019/03/05/US10221175B2/abs.jpg.150x150.jpg)
Abstract:
Substituted pyrrolopyridine, imidazopyridine and triazolopyridine compounds having a formula are positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1) and the compounds and their pharmaceutical compositions may be useful in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Compounds of the invention may be prepared in several steps from 2-halo-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one intermediates.
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