Invention Grant
- Patent Title: 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
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Application No.: US15526642Application Date: 2015-11-12
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Publication No.: US10221181B2Publication Date: 2019-03-05
- Inventor: Laura Buffa , Maria Menichincheri , Ilaria Motto , Francesca Quartieri
- Applicant: NERVIANO MEDICAL SCIENCES S.r.l.
- Applicant Address: IT Nerviano (MI)
- Assignee: NERVIANO MEDICAL SCIENCES S.r.l.
- Current Assignee: NERVIANO MEDICAL SCIENCES S.r.l.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP14193197 20141114
- International Application: PCT/EP2015/076411 WO 20151112
- International Announcement: WO2016/075224 WO 20160519
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P35/04 ; A61P35/02
Abstract:
6-Amino-7-bicyclo-7-deaza-purine derivatives of formula (I): modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
Public/Granted literature
- US20170327506A1 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS Public/Granted day:2017-11-16
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