Invention Grant
- Patent Title: 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
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Application No.: US15548594Application Date: 2016-02-03
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Publication No.: US10221182B2Publication Date: 2019-03-05
- Inventor: Gideon Shapiro
- Applicant: Rugen Holdings (Cayman) Limited
- Applicant Address: KY Grand Cayman
- Assignee: RUGEN HOLDINGS (CAYMAN) LIMITED
- Current Assignee: RUGEN HOLDINGS (CAYMAN) LIMITED
- Current Assignee Address: KY Grand Cayman
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- International Application: PCT/US2016/016442 WO 20160203
- International Announcement: WO2016/126869 WO 20160811
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/55 ; A61P25/00 ; A61P25/24 ; A61P25/28 ; A61P25/08
Abstract:
Disclosed are chemical entities of Formula (I): wherein X, Y, Z, R1, R3, R4 and R5 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).
Public/Granted literature
- US20180030055A1 3,3-DIFLUORO-PIPERIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS Public/Granted day:2018-02-01
Information query
