Invention Grant
- Patent Title: Spirocyclic heterocyclic compounds useful as HIV integrase inhibitors
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Application No.: US15533169Application Date: 2015-12-04
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Publication No.: US10221186B2Publication Date: 2019-03-05
- Inventor: Mark W. Embrey , Thomas H. Graham , Izzat T. Raheem , John D. Schreier , Sherman T. Waddell , John S. Wai , Lihong Hu , Xuanjia Peng
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Todaro
- Priority: WOPCT/CN2014/093335 20141209
- International Application: PCT/US2015/063850 WO 20151204
- International Announcement: WO2016/094197 WO 20160616
- Main IPC: A61K31/499
- IPC: A61K31/499 ; A61K31/675 ; A61K31/683 ; C07F9/6561 ; C07D487/20 ; C07D491/20 ; A61K45/06 ; A61P31/18
Abstract:
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Public/Granted literature
- US20170334924A1 Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors Public/Granted day:2017-11-23
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