Invention Grant
- Patent Title: Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
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Application No.: US15807143Application Date: 2017-11-08
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Publication No.: US10221205B2Publication Date: 2019-03-05
- Inventor: David Tellers , Steven L. Colletti , Vadim Dudkin , Jeffrey Aaronson , Aaron Momose , Thomas Joseph Tucker , Yu Yuan , Kathleen B. Calati , Lu Tian , Rubina G. Parmar , Anthony W. Shaw , Weimin Wang , Rachel Anne Storr , Marina Busuek , Robert A. Kowtoniuk
- Applicant: Sirna Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Sirna Therapeutics, Inc.
- Current Assignee: Sirna Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Cozen O'Connor
- Agent Jeffrey N. Townes
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H15/26 ; A61K31/713 ; A61K47/26 ; A61K31/7056 ; A61K47/54
Abstract:
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Public/Granted literature
- US20180079769A1 NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES Public/Granted day:2018-03-22
Information query
IPC分类:
