Invention Grant
- Patent Title: HER-1, HER-3 and IGF-1R compositions and uses thereof
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Application No.: US14770335Application Date: 2014-02-25
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Publication No.: US10221230B2Publication Date: 2019-03-05
- Inventor: Pravin T. P. Kaumaya
- Applicant: OHIO STATE INNOVATION FOUNDATION
- Applicant Address: US OH Columbus
- Assignee: Ohio State Innovation Foundation
- Current Assignee: Ohio State Innovation Foundation
- Current Assignee Address: US OH Columbus
- Agency: Meunier Carlin & Curfman LLC
- International Application: PCT/US2014/018354 WO 20140225
- International Announcement: WO2014/131019 WO 20140828
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/72 ; A61K9/00 ; C12Q1/6883 ; A61K39/00 ; C07K16/28 ; C07K16/32 ; A61K47/34 ; A61K47/44 ; C07K14/435 ; C07K14/475 ; C07K14/82 ; A61K47/65 ; A61K47/64 ; A61K38/00
Abstract:
Provided herein are HER-3, HER-1 and IGF-1R B cell epitopes, peptide mimics, chimeric peptides and multivalent peptides. In some embodiments, the chimeric peptides include one or more HER-3, HER-1 and/or IGF-1R B cell epitopes, a linker, and a T helper cell (Th cell) epitope. Pharmaceutical compositions are also provided that contain one or more HER-3, HER-1 and/or IGF-1R chimeric peptides, and optionally, one or more HER-2 chimeric peptides and/or VEGF peptides. Also included herein are methods of treating a cancer using the HER-3, HER-1 and IGF-1R B cell epitopes, chimeric peptides and multivalent peptides.
Public/Granted literature
- US20160002313A1 HER-1, HER-3 AND IGF-1R COMPOSITIONS AND USES THEREOF Public/Granted day:2016-01-07
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