Disclosed are a sealing adhesive and a method of making the same, and a liquid crystal display device. The sealing adhesive includes a modified epoxy compound obtained by chemical bonding of a piperidine compound with an epoxy compound, wherein the modified epoxy compound contains a nitrogen-hydrogen bond. The method of preparing the above sealing adhesive includes: subjecting a piperidine compound and an epoxy compound to a chemical reaction to obtain a modified epoxy compound; and mixing about 10 to 90 parts by eight of the modified epoxy compound, about 10 to 90 parts by weight of an acrylic resin, about 2 to 5 parts by weight of a filler, about 5 to 10 parts by weight of a heat curing agent and about 3 to 10 parts by weight of a photoinitiator to obtain a sealing adhesive. The liquid crystal display device includes the sealing adhesive described above.