The disclosed subject matter includes embodiments of fluid couplings that prevent or discourage misconnection of fluid lines. In embodiments, a coupling device may have multiple male connectors, female connectors, open ports, butt connectors, and plugs that close off various ports and connectors. The coupling device is mated to a matching coupling device only when all the multiple male and female connectors are properly joined and/or sealed by plugs. If any of the connectors is not properly mated to a corresponding one or not sealed by a plug on the opposite connector, the coupling will leak, since the connectors are joined to a furcating channel.