An active probe adapter adapts an active probe to a PXI instrumentation module. The active probe adapter includes a first module interface (MI) connector on a first side of the active probe adapter. The first MI connector is configured to connect to a corresponding interface connector of the PXI instrumentation module. The active probe adapter further includes a plurality of probe pads on a second side of the active probe adapter opposite to the first side. The plurality of probe pads is configured to interface with an active probe employed with the PXI instrumentation module. The active probe adapter may include a second MI connector on the active probe first side configured to connect to a PXI power module and provide power to the active probe.