Invention Grant
- Patent Title: Method and apparatus for tiling light sheet selective plane illumination microscopy with real-time optimized light sheet
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Application No.: US15552893Application Date: 2016-02-23
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Publication No.: US10222600B2Publication Date: 2019-03-05
- Inventor: Liang Gao
- Applicant: The Research Foundation for The State University of New York
- Applicant Address: US NY Albany
- Assignee: The Research Foundation for The State University of New York
- Current Assignee: The Research Foundation for The State University of New York
- Current Assignee Address: US NY Albany
- Agency: The Farrell Law Firm, P.C.
- Agent John F. Gallagher, III
- International Application: PCT/US2016/019143 WO 20160223
- International Announcement: WO2016/138003 WO 20160901
- Main IPC: G02B21/06
- IPC: G02B21/06 ; G02B21/36 ; G01N21/64 ; G01N15/14 ; G02B21/16 ; G01N15/00 ; G01N15/10
Abstract:
Disclosed are a method and apparatus for tiling light sheet selective plane illumination microscopy (TLS-SPIM) with real-time light sheet optimization. The method and apparatus image multi-cellular specimens in 3D, with an improved 3D imaging ability of SPIM in resolving complex structures and optimizes SPIM live imaging performance by using a real-time adjustable tiling light sheet and creating a flexible compromise between spatial and temporal resolution. A 3D live imaging ability is provided of the TLS-SPIM by real-time imaging cellular and sub-cellular behaviors.
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