A remote isolation system (10) for a plant comprising equipment (20,21) energizable by an energy source (30) and a control system (50,260) enabling automated isolation of the equipment (20,21) from said energy source (30) to an isolated state when authorized by the control system (50,260), wherein said control system (50,260) enables remote isolation of the equipment (20,21) by one or more mobile isolation device(s) (120) provided as part of the remote isolation system (10) and configured to request the control system (50,260) to authorize equipment (20,21) isolation.