A device (15) for piloting a drone (10) comprising a touch screen (18) displaying a touch-sensitive area, means for detecting signals emitted by the touch-sensitive area, and means for transforming said detected signals into piloting commands and transmitting said commands to the drone. The device comprises control means, controlled by the touch-sensitive area forming activation/deactivation button, to make the drone piloting mode alternately switch between a mode of activation of the system for holding the last detected commands, mode in which said piloting commands transmitted to the drone result from the transformation of the last detected signals before the switching to the activation mode, and a mode of deactivation of the system for holding the last detected commands, mode in which said piloting commands transmitted to the drone result from the transformation of the current detected signals. The invention also relates to an associated method for controlling a drone.