Disclosed aspects relate to memory affinity management in a shared pool of configurable computing resources that utilizes non-uniform memory access (NUMA). An access relationship is monitored between a set of hardware memory components and a set of software assets. A set of memory affinity data is stored. The set of memory affinity data indicates the access relationship between the set of software assets and the set of hardware memory components. Using the set of memory affinity data, a NUMA utilization configuration with respect to the set of software assets is determined. Based on the NUMA utilization configuration, a set of accesses pertaining to the set of software assets and the set of hardware memory components is executed.