Provided herein are systems and methods for measurement and compensation of display panel current leakage and/or display panel noise. A pixel data signal is received at sensing and compensation circuitry. Current leakage compensation circuitry compensates for current leakage of the display panel in the data signal, while panel noise mitigation circuitry configured to reduce panel noise from the data signal. After compensating for the current leakage and reducing the panel noise, the data signal is provided to downstream circuitry for subsequent processing.