The present application provides an OLED package structure, comprises a package unit and a flexible substrate deposited with an OLED element; the package unit comprises a first package layer, a first inorganic layer and a second package layer, which sequentially stack up on the OLED element; the first package layer comprises a first pixel region and a first pixel define region, and the film thickness of the first pixel define region gradually decreases from an edge to an interior of the first pixel define region; the second package layer comprises a second pixel region corresponding to the first pixel region and a second pixel define region corresponding to the first pixel define region, and the film thickness of the second pixel region gradually decreases from an edge to an interior of the second pixel region. The present application further provides an OLED package method.