Resistor mismatch may be digitally compensated based on a known resistor mismatch, power supply information, and/or other operating parameters of the amplifier. The digital compensation may be applied to the digital input signal before conversion for processing and amplification in the analog domain. An amplifier with digital compensation for resistor mismatch may be used in a class-D amplifier with a closed loop and feedforward feedback. A class-D or other amplifier with digital compensation may be integrated with electronic devices such as mobile phones.