In accordance with an embodiment, described herein is a system and method for supporting interceptors in an application server environment. The method can provide, at one or more computers, including an application server environment executing thereon, a plurality of deployable resources which can be used within the application server environment, one or more partitions, wherein each partition provides an administrative and runtime subdivision of a domain, and an interceptor framework, the interceptor framework comprising a plurality of interceptors. The method can further select and trigger, on a call for a method invocation, an interceptor chosen from the plurality of interceptors. The method can interrupt, by the triggered interceptor, the call for the method invocation, wherein the interceptor is selected based at least upon the call for a method invocation.