A method is provided for operating an imaging system to maintain a tunable acoustic gradient (TAG) lens at a desired operating state. In a first step, the TAG lens operates using a standard imaging drive control configuration (e.g., a standard drive voltage and duration) during a plurality of imaging drive mode time periods, to achieve a standard imaging state of the TAG lens. In a second step, the TAG lens operates using a regulating adaptive drive control configuration during a plurality of regulating adaptive drive mode time periods, wherein at least one of a different respective TAG lens drive voltage and a different respective TAG lens drive duration is used for different respective regulating adaptive drive mode time periods, based on a monitoring signal that is indicative of a difference between the standard imaging state and a current operating state of the TAG lens.