A method and apparatus for enhanced uplink communication is disclosed. A Node-B receives a scheduling request from a wireless transmit/receive unit (WTRU). The Node-B determines a scheduling grant based at least on the scheduling request. The Node-B transmits the scheduling grant to the WTRU. The Node-B demultiplexes a received medium access control for enhanced uplink (MAC-e) protocol data unit (PDU), from the WTRU, into medium access control for dedicated channel (MAC-d) PDUs. The Node-B generates and sends a transmission feedback in response to the received MAC-e PDU.