An electronic device with a seal member is provided. The electronic device includes a tray configured to slide in and out of the electronic device, an opening, (e.g., a hole) formed at one side of the tray, for communicating outside of the electronic device, a socket disposed in the electronic device, the tray slides into or from the socket, and a seal member, disposed between the opening and the socket, for performing a waterproof and dustproof function. Various types of the seal member may be implemented.