Invention Grant
- Patent Title: FK506 derivative maintaining nerve regeneration activity without immunosuppressive activity, and use thereof
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Application No.: US15500353Application Date: 2015-07-31
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Publication No.: US10226446B2Publication Date: 2019-03-12
- Inventor: Yeo Joon Yoon , Ho Jeong Kwon , Yeon Hee Ban , Shinde Pramodb
- Applicant: INTRON BIOTECHNOLOGY CO., LTD
- Applicant Address: KR Seongnam-si
- Assignee: INTRON BIOTECHNOLOGY CO., LTD
- Current Assignee: INTRON BIOTECHNOLOGY CO., LTD
- Current Assignee Address: KR Seongnam-si
- Agency: Seed IP Law Group LLP
- Priority: KR10-2014-0099210 20140801
- International Application: PCT/KR2015/008031 WO 20150731
- International Announcement: WO2016/018117 WO 20160204
- Main IPC: A61K31/436
- IPC: A61K31/436 ; A61K31/4025 ; C12P17/16
Abstract:
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing or treating nervous system diseases. A composition comprising 9-deoxo-prolyl-FK506, 31-O-demethyl-FK506, or 9-deoxo-31-O-demethyl-FK506 can promote nerve regeneration and has reduced immunosuppressive activity, thereby reducing side effects in the treatment of nervous system diseases.
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