Invention Grant
- Patent Title: Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
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Application No.: US15346443Application Date: 2016-11-08
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Publication No.: US10226452B2Publication Date: 2019-03-12
- Inventor: Daniele Piomelli , Chiara Pagliuca , Daniela Pizzirani , Anders Bach , Natalia Realini , Marco De Vivo
- Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US CA Oakland IT Genoa
- Assignee: The Regents of the University of California,Fondazione Istituto Italiano di Tecnologia
- Current Assignee: The Regents of the University of California,Fondazione Istituto Italiano di Tecnologia
- Current Assignee Address: US CA Oakland IT Genoa
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Agent Anson M. Nomura
- Priority: ITMI2014A0863 20140512
- Main IPC: A61K31/423
- IPC: A61K31/423 ; A61K31/4439 ; A61K45/06 ; C07D263/58 ; C07D413/12
Abstract:
The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
Public/Granted literature
- US20170182010A1 BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS Public/Granted day:2017-06-29
Information query
IPC分类:
