Invention Grant
- Patent Title: Therapeutic IL-13 polypeptides
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Application No.: US15597823Application Date: 2017-05-17
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Publication No.: US10227389B2Publication Date: 2019-03-12
- Inventor: Kenan Christopher Garcia , Ignacio Moraga Gonzalez
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Morgan Lewis & Bockius LLP
- Main IPC: C07K14/54
- IPC: C07K14/54 ; C07K16/00 ; A61K38/20
Abstract:
Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13Rα2, relative to the native human IL-13 protein; (b) altered affinity for IL-13Rα1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4Rα relative to the native human IL-13 protein.
Public/Granted literature
- US20170246251A1 THERAPEUTIC IL-13 POLYPEPTIDES Public/Granted day:2017-08-31
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