A method, system, and computer program product for subject-matter analysis of tabular data are provided in the illustrative embodiments. A first document including the tabular data is received. A library of functional signatures for a first subject-matter domain is selected. A determination is made whether a threshold number of functional signatures from the selected library are applicable to the tabular data, wherein a functional signature is applicable to the tabular data when values in the tabular data correspond to an operation and a table structure specified in the functional signature. Responsive to the threshold number of functional signatures from the selected library being applicable to the tabular data, a processor and a memory process the first document according to a process for the first subject matter domain selected from a plurality of processes for respective subject matter domains.