A high-voltage startup circuit in an integrated circuit with a high-voltage pin and an operating voltage pin is disclosed, capable of having both low standby power consumption and high-speed transient response. An ultra-high voltage transistor and a main NMOS transistor are connected in series via a joint node between the high-voltage pin and the operating voltage pin. A pull-up circuit controlled by a stop signal is connected between the joint node and a first gate of the main NMOS transistor. A pull-down circuit controlled by the stop signal is connected to the first gate of the main NMOS transistor. When the stop signal is de-asserted the pull-up circuit couples the joint node to the first gate. When the stop signal is asserted the pull-up circuit performs an open circuit and the pull-down circuit pulls down the first gate voltage.