Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a radio receiver with a hybrid channelizer architecture. In some implementations, a receiver includes an input to receive a first signal encoding digital samples of a radiofrequency signal. The receiver includes a frequency shifter configured to generate a second signal that is frequency shifted relative to the first signal. The receiver includes a first polyphase filter bank configured to receive the first signal and provide filter bank outputs for first sub-bands. The receiver includes a second polyphase filter bank configured to receive the second signal and provide filter bank outputs for second sub-bands. The receiver includes a switch network configured to select among the filter bank outputs and provide the filter bank outputs to respective digital channelizer modules for multiple channels.