Controlling the uplink transmission power includes dynamically activating and deactivating a high-power transmission mode of the wireless devices in response to changes in a network topology, such as presence or absence of different types of access nodes, and signal level measurements of reference signals transmitted from said different types of access nodes. Such dynamic control of the uplink transmission power in real time minimizes interference that may be caused to uplink transmissions of other wireless devices in the network, and mitigates unnecessary power consumption for wireless devices capable of utilizing the high-power mode.