Disclosed in the present invention are a multi-user (MU) transmission method in a wireless communication system and a device therefor. Specifically, the MU transmission method in a wireless communication system comprises a step in which a station (STA) receives, from an access point (AP), an allocation frame comprising resource allocation information for the MU transmission, wherein the allocation frame may comprise indication information for indicating whether the resource allocation information indicates a frequency resource for orthogonal frequency division multiple access (OFDMA) transmission, or indicates a spatial resource for MU multi-input multi-output (MIMO) transmission.