The present disclosure provides a method and device for processing Device-to-Device (D2D) communication, a D2D communication device and an Evolved Node B (eNodeB). Wherein, the method includes that: resources configured for Scheduling Assignment (SA) and/or data of D2D communication are divided into M resource groups, each resource group including X ResourceUnits (RUs) formed by N time-domain RUs*K frequency-domain RUs, each RU including O symbols on a time domain and including P subcarriers on a frequency domain, the X RUs in each resource group being configured to configure T logical channels, each logical channel including Num RUs according to a number Num of sending times and locations of each logical channel in the resource groups being determined according to a preset rule; and D2D communication processing is performed according to a determined resource configuration.