A combine harvester includes a threshing unit for threshing picked-up crop to obtain grain, a driver assistance system, with a memory for storing data, for controlling the threshing unit, and a computing unit for processing at least the data stored in the memory. A sensor system ascertains at least a portion of the current harvesting-process state. A sensor configuration assigned to the sensor system is defined by the type and scope of operational sensors is stored or can be stored in the memory. A functional system model for at least a portion of the combine harvester is stored in the memory. The computing unit is designed to carry out an autonomous determination of a threshing-unit parameter based on the system model, and defines the system model forming a basis of the control of the threshing unit depending on the sensor configuration stored in the memory.