- Patent Title: Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications
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Application No.: US14906111Application Date: 2014-07-16
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Publication No.: US10231991B2Publication Date: 2019-03-19
- Inventor: Anirudha Singh , Shimon Unterman , Michael Corvelli , Jennifer Elisseeff
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: John Hopkins Technology Ventures
- International Application: PCT/US2014/046796 WO 20140716
- International Announcement: WO2015/009787 WO 20150122
- Main IPC: A61K9/00
- IPC: A61K9/00 ; C08L5/08 ; A61K38/08 ; A61K38/10 ; A61K47/60 ; A61K47/69 ; A61L27/20 ; A61L27/22 ; A61K31/728

Abstract:
The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.
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