Invention Grant
- Patent Title: Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
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Application No.: US15834690Application Date: 2017-12-07
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Publication No.: US10232053B2Publication Date: 2019-03-19
- Inventor: Daniel Hicklin , Kenneth Nelson Wills , Cynthia Seidel-Dugan , William Winston , Philipp Steiner
- Applicant: Trieza Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Trieza Therapeutics, Inc.
- Current Assignee: Trieza Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: A61K35/761
- IPC: A61K35/761 ; A61P35/00 ; C12N15/861 ; A61K48/00 ; C07K14/705 ; C07K14/54 ; C12N15/86 ; A61K39/00
Abstract:
Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.
Public/Granted literature
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