Invention Grant
- Patent Title: Composition for mRNA delivery
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Application No.: US15118407Application Date: 2014-02-12
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Publication No.: US10232054B2Publication Date: 2019-03-19
- Inventor: Kazunori Kataoka , Keiji Itaka , Takehiko Ishii , Hirokuni Uchida , Satoshi Uchida , Miyuki Baba
- Applicant: AccuRna, Inc.
- Applicant Address: JP Bunkyo-ku
- Assignee: AccuRna, Inc.
- Current Assignee: AccuRna, Inc.
- Current Assignee Address: JP Bunkyo-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- International Application: PCT/JP2014/053190 WO 20140212
- International Announcement: WO2015/121924 WO 20150820
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/7105 ; A61K38/18 ; A61K9/00 ; A61K47/34 ; A61K31/7115 ; A61K9/107 ; C12N15/87 ; A61K38/17 ; A61K47/10

Abstract:
A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.
Public/Granted literature
- US20170173182A1 COMPOSITION FOR mRNA DELIVERY Public/Granted day:2017-06-22
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