- Patent Title: CEST systems exhibiting a concentration independent responsiveness
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Application No.: US13879083Application Date: 2011-11-04
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Publication No.: US10232060B2Publication Date: 2019-03-19
- Inventor: Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Dario Livio Longo , Enzo Terreno , Fulvio Uggeri
- Applicant: Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Dario Livio Longo , Enzo Terreno , Fulvio Uggeri
- Applicant Address: IT Milan
- Assignee: BRACCO IMAGING S.P.A.
- Current Assignee: BRACCO IMAGING S.P.A.
- Current Assignee Address: IT Milan
- Agency: Vivicar Law, PLLC
- Priority: EP10190161 20101105
- International Application: PCT/EP2011/069406 WO 20111104
- International Announcement: WO2012/059576 WO 20120510
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; A61K49/10 ; G01R33/56
Abstract:
The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.
Public/Granted literature
- US20130195768A1 CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS Public/Granted day:2013-08-01
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