Invention Grant
- Patent Title: Substituted spirocyclic inhibitors of autotaxin
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Application No.: US15896905Application Date: 2018-02-14
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Publication No.: US10233182B2Publication Date: 2019-03-19
- Inventor: Lee Babiss , Matthew Clark , Anthony D. Keefe , Mark J. Mulvihill , Haihong Ni , Louis Renzetti , Frank Ruebsam , Ce Wang , Zhifeng Xie , Ying Zhang
- Applicant: X-Rx, Inc.
- Applicant Address: US MA Waltham
- Assignee: X-Rx, Inc.
- Current Assignee: X-Rx, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Clark & Elbing LLP
- Main IPC: C07D221/00
- IPC: C07D221/00 ; C07D233/00 ; A61K31/4545 ; A61K31/415 ; A61K31/454 ; C07D471/10 ; A61K45/06 ; A61K31/435 ; A61K31/437 ; A61K31/444 ; A61K31/498 ; A61K31/517 ; A61K31/538 ; A61K31/69 ; C07D519/00 ; C07F5/02
Abstract:
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
Public/Granted literature
- US20180282332A1 SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN Public/Granted day:2018-10-04
Information query
