- Patent Title: Peptide having eight amino acid sequences derived from cage and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug-resistant cancer cells
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Application No.: US15815780Application Date: 2017-11-17
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Publication No.: US10233221B2Publication Date: 2019-03-19
- Inventor: Doo II Jeoung , Young Mi Kim , Hyun A Kim
- Applicant: L-Base Co., Ltd.
- Applicant Address: KR Seoul
- Assignee: L-BASE CO., LTD.
- Current Assignee: L-BASE CO., LTD.
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2014-0183218 20141218
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/00 ; C07K7/06 ; C07K7/00 ; C07K14/47 ; A61K45/06 ; A61K31/192 ; A61K31/337

Abstract:
A peptide having eight amino acid sequences derived from cancer-associated gene (CAGE) is described which retains anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells. Specifically, a peptide which has an amino acid sequence of SEQ ID NO: 1 (AQTGTGKT) and thus binds to the CAGE protein is disclosed, which inhibits an inter-linkage between CAGE and GSK3β, thus exhibiting anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells. A pharmaceutical composition is also disclosed containing the peptide with the amino acid sequence of SEQ ID NO: 1 (AQTGTGKT), for anticancer use or anticancer drug aiding.
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