Invention Grant
- Patent Title: Differentiation of pluripotent stem cells
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Application No.: US15457893Application Date: 2017-03-13
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Publication No.: US10233421B2Publication Date: 2019-03-19
- Inventor: Janet Davis , Jiajian Liu , Christine Parmenter , Pascal Ghislain Andre Bonnet
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/0735
Abstract:
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
Public/Granted literature
- US20170183625A1 DIFFERENTIATION OF PLURIPOTENT STEM CELLS Public/Granted day:2017-06-29
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