Embodiments of the invention relate to a system and method to enable and support vertical installation of a rack server midplane. The system is comprised of two primary components, including a guide and a bracket. The guide is secured to a server chassis, and is sized to receive the bracket. Upon receipt of the bracket, the bracket is held in position by the guide. The bracket is configured to frictionally hold the midplane in position. Installation of the bracket with the midplane within the chassis includes a direct installation of the bracket to the guide and an indirect installation of the midplane to the guide.