Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to assess image quality using adaptive non-overlapping mean estimation are disclosed. Example image quality assessment methods disclosed herein include replacing respective blocks of pixels of a first image with mean values of the respective blocks of pixels to determine a second image having a smaller size than the first image. Disclosed example image quality assessment methods also include determining a vector of features for the second image. Disclosed example image quality assessment methods further include applying the vector of features to a neural network, and classifying a quality of the first image based on an output of the neural network.