According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided. The method comprises computing a boundary of a portion of the vasculature based on the geometric representation, logically dividing the geometric representation within the boundary into a plurality of regions, and analyzing at least one feature for each of the plurality of regions within the boundary.