A system deploys electronic countermeasures against unmanned aerial vehicles (UAVs) that are determined to be a threat. A radio transceiver coupled to at least one antenna detects if radio signals are being communicated between a remote control unit and a UAV. A mitigation engine communicatively coupled to the radio transceiver synthesizes an exploit signal to be transmitted to the UAV, wherein the exploit signal is configured to inject commands into the UAV's navigation system. If the system determines that the UAV is operating in an autopilot mode, it transmits an induce-mode signal that causes the UAVs to switch to a communication mode so the UAV is responsive to the exploit signal.