A method for anticipatory or predictive operation of a motor vehicle having a drive control system by which drive-relevant components of the drive-train are adjusted, and a detection system by which a travel route and anticipated driving time to a specified destination as well as the current position of the vehicle are determined. By way of the detection system and based on topographical information, a driving resistance profile of the route is prepared, to parameterize the drive control system such that the route is driven in a specifiable manner. If a need arises during the journey, a nominal arrival time or a travel route is specified or modified and, in accordance with the specified or changed nominal arrival time or route, the drive control system is dynamically re-parameterized so that the vehicle reaches its destination at the time concerned with regard to an efficient mode of operation.