Invention Grant
- Patent Title: Fused cyclooctyne compounds and their use in metal-free click reactions
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Application No.: US14978924Application Date: 2015-12-22
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Publication No.: US10239807B2Publication Date: 2019-03-26
- Inventor: Floris Louis Van Delft , Floris Petrus Johannes Theodorus Rutjes , Frederik Jan Dommerholt
- Applicant: SynAffix B.V.
- Applicant Address: NL Oss
- Assignee: SynAffix B.V.
- Current Assignee: SynAffix B.V.
- Current Assignee Address: NL Oss
- Agency: Foley & Lardner LLP
- Agent Gilberto M. Villacorta; Sunit Talapatra
- Priority: EP10161192 20100427
- Main IPC: C07C33/16
- IPC: C07C33/16 ; C07C271/10 ; C07C271/20 ; C07C29/147 ; C07C29/58 ; C07C29/62 ; C07C269/04 ; C07C67/347 ; A61K47/54 ; A61K49/00 ; G01N33/58 ; G01N33/532 ; C07C271/12 ; C07C62/30 ; C07C269/06 ; C07D311/82 ; C07D495/04 ; C07K14/47 ; G01N21/64
Abstract:
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
Public/Granted literature
- US20160214917A1 FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS Public/Granted day:2016-07-28
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