Invention Grant
- Patent Title: Process for the preparation of (1R,3R)- and (1S,3S)-2,2-dihalo-3-(substituted phenyl)cyclopropanecarboxylic acids
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Application No.: US15727651Application Date: 2017-10-09
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Publication No.: US10239817B2Publication Date: 2019-03-26
- Inventor: Nakyen Choy , Fangzheng Li
- Applicant: Dow AgroSciences LLC
- Applicant Address: US IN Indianapolis
- Assignee: Dow AgroSciences LLC
- Current Assignee: Dow AgroSciences LLC
- Current Assignee Address: US IN Indianapolis
- Main IPC: C07C51/50
- IPC: C07C51/50 ; C07C61/40 ; C07C51/487
Abstract:
The (1R,3R)- or (1S,3S)-enantiomer of 2,2-dichloro-3-(substituted phenyl)cyclopropane-carboxylic acid is prepared in a process involving chemical resolution of a racemic mixture of a trans-2,2-dichloro-3-(substituted phenyl)cyclopropanecarboxylic acid with an enantiomeric amine, isolation of a diastereomeric amine salt and finally treatment of the salt with an acid.
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