- Patent Title: Synthesis of resorcylic acid lactones useful as therapeutic agents
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Application No.: US14691880Application Date: 2015-04-21
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Publication No.: US10239856B2Publication Date: 2019-03-26
- Inventor: Nicolas Winssinger , Sofia Barluenga , Martin Karplus
- Applicant: Nicolas Winssinger , Sofia Barluenga , Martin Karplus
- Applicant Address: FR Strasbourg
- Assignee: UNIVERSITY DE STRASBOURG
- Current Assignee: UNIVERSITY DE STRASBOURG
- Current Assignee Address: FR Strasbourg
- Agency: Cooley LLP
- Main IPC: C07D313/00
- IPC: C07D313/00 ; C07D211/14 ; C07D225/06 ; C07D405/12 ; C07D405/14 ; A61K31/365 ; A61K31/4025 ; A61K31/4523 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/541 ; A61K31/435 ; A61K31/4453 ; A61K31/335
Abstract:
Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
Public/Granted literature
- US20160075677A1 SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS Public/Granted day:2016-03-17
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