Invention Grant
- Patent Title: Factor XIa inhibitors
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Application No.: US15789088Application Date: 2017-10-20
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Publication No.: US10239863B2Publication Date: 2019-03-26
- Inventor: Ning Shao , Scott D. Edmondson , Santhosh Neelamkavil , Zhuyan Guo , Eric Mertz , Yi Zang , Jiafang He
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Todaro
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/10 ; C07C269/06 ; C07D413/14 ; C07D401/04
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Public/Granted literature
- US20180179180A1 Factor XIa Inhibitors Public/Granted day:2018-06-28
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