Invention Grant
- Patent Title: Modulation of synaptic maintenance
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Application No.: US15222603Application Date: 2016-07-28
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Publication No.: US10240156B2Publication Date: 2019-03-26
- Inventor: Ben A. Barres , Alexander H. Stephan , Beth A. Stevens
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/00 ; A61K31/727 ; A61K45/06 ; G01N33/50 ; G01N33/564 ; G01N33/68 ; A61K38/17 ; A61K38/48 ; A61K31/7088 ; A61K48/00
Abstract:
C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.
Public/Granted literature
- US20160326534A1 MODULATION OF SYNAPTIC MAINTENANCE Public/Granted day:2016-11-10
Information query
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