Embodiments of the present invention provide a system, method, and program product for domain based resource isolation in multi-core systems. A computing device determines an operation being attempted on a workload request identified with a first domain identifier. The computing device determines a processor core identified with a second domain identifier. In response to determining that processor cores identified with the second domain identifier can service workload requests identified with the first domain identifier, the computing device deploys the workload request to the processor core for servicing.